david stevens archaeologist

Significant differences in drug susceptibility among species in the Candida parapsilosis group. Chronic necrotizing aspergillosis, aspergilloma, and allergic bronchopulmonary aspergillosis have variable management strategies and better short-term outcomes. In experimental candidiasis, several manipulations of the immune system, via administration of cytokines, gene deletion or antibodies to cytokines, have been shown to significantly affect survival and fungal clearance in vivo. HKY also induced antibody against Saccharomyces glucan and mannan with titers 4- or 2-fold, respectively, above that in unvaccinated. In all studies, 90% of mice infected with 10(7) CFU of YJM128 died between days 2 and 7, whereas no mice infected with equivalent numbers of Y55 died. The median kidney or liver CFU were 2 or 3 log(10) CFU, respectively, on day 15; despite this, mortality was low through 21 days of infection. These results further support a role for 17beta-estradiol during early innate resistance of females to paracoccidioidomycosis. In a multiplex analysis, 192 genotypes were obtained and the combined discriminatory power of the four microsatellites was 0.99. Assessment of the individual contribution of each mediator to vasculitis may offer novel approaches to the treatment of coccidioidal CNS infection. A 16.5% salt concentration in brain-heart infusion broth, incubated at 35 degrees C for 48-72 hours, then subcultured to agar plates incubated in room air at 35 degrees C, proved optimal for selection and secondary isolation. By the sandwich immunofluorescent antibody (IFA) method with anti-mouse MBL (MBL-A or -C), we showed that serum MBL bound to B. dermatitidis. Imai, J., Singh, G., Fernandez, B., Clemons, K. V., Stevens, D. A. Help keep Alice Roberts and David Stevens profile up to date. [4][1], Whilst appointed as Medical Officer, Stevens reported that disease was being spread by polluted water and poor hygiene and informed support for significant health legislations including the 1866 Sanitary Act which had been hastened by the cholera epidemic. IL-4, IL-6, and gamma interferon transcripts were detected on day 5, and IL-1 beta and IL-10 transcripts were detected beginning on day 7. S. cerevisiae will be a useful model for the evolution and genetic analysis of fungal virulence and the study of polygenic traits. Does the lack of increase in CFU as infection worsens inadequately reflect fungal load in the tissue? Groups of 10 received 0.8, 4, or 8 mg/kg of Abelcet, intravenously (iv), or caspofungin, intraperitoneally, 0.8 mg/kg of conventional amphotericin B (AmB) iv, or no treatment. Field of expertise. The pharmacokinetics for both conventional and intermittent dosing were linear. CD-1 mice were infected intrathecally with 30 to 36 viable arthroconidia of Coccidioides. My career ambitions havent changed much, in that my main ambition is to work hard at whatever I apply myself to. 0 people commented on this, Posted on July 24, 2014 White, T. C., Holleman, S., Dy, F., Mirels, L. F., Stevens, D. A. fos-1, a putative histidine kinase as a virulence factor for systemic aspergillosis. The AUC for these enzymes was also similar in the two groups. Although groups of rabbits treated with AmBi regimens did not have significantly fewer animals with meningitis than the control group (P > 0.05), ABLC and AmBi were not significantly different. Best Match Powered by Whitepages Premium AGE -- David Stevens Little Neck, NY (Northeastern Queens) View Full Report Addresses 68th Ave, Little Neck, NY Phone Numbers (718) I am an archeologist (UCL) and award-winning lecturer and researcher and have worked in archeological projects in Armenia, Europe and the UK and travelled extensively on academic research including Syria, Jordan, USA and Japan. With Aspergillus fumigatus synergy was noted for inhibition and killing, and synergistic activity was also noted for some isolates of other species presently regarded as difficult to treat. It describes a range of group problem solving methodologies and illustrates vividly how they can aid modern business. Recently, selected cationic heterocyclic compounds belonging to a broad class of molecules known to bind to the minor groove of DNA were revealed to have potent antifungal activity. Beta-1,3-glucan declined 81% in the presence of caspofungin, as expected. Combination therapy using available drugs is an attractive choice, yet primarily only anecdotal clinical data are available. Fungal burdens in brains and kidneys were reduced after > 0.3 mg of mannan-BSA (all P < 0.05). A., Wu, T. D., Shankar, J., Lopes, C. R., Stevens, D. A. Halomonas, a Newly Recognized Human Pathogen Causing Infections and Contamination in a Dialysis Center Three New Species. Patients presenting with paraplegia had a poor outcome. Fifty-eight patients received > or = 300 mg/day, and 7 received > or = 600 mg/day. > present (Honorary Fellow of the British Science Association and the Royal Society of Biology), [????] Stevens, D. A., Kan, V. L., Judson, M. A., Morrison, V. A., Dummer, S., Denning, D. W., BENNETT, J. E., Walsh, T. J., Patterson, T. F., Pankey, G. A. In May 2007, 2 patients developed, days apart, bacteremia with an apparently identical nonfermentative Gram-negative rod. The rate of adverse events was similar in the two groups. We used EcoRI digestion of cellular DNA to generate RFLP; RAPD analysis on genomic DNA. View details for Web of Science ID 000177999000007. When VCZ was combined with monocytes or monocytes were treated with GM-CSF, inhibition was significantly increased, to similar levels. Currently, few options exist to treat central nervous system (CNS) aspergillosis, which is usually fatal. No monotherapy regimen was superior to another. Kline, Y., Clemons, K. V., Woods, L., Stevens, D. A., Tell, L. A. View details for Web of Science ID 000175084400015. One isolate, 95-68, showed paradoxical growth in vivo with significantly higher CFU recovered from mice given CAS at 20 mg/kg than those given CAS at 5 mg/kg, but the effect was not reproducible in a subsequent experiment. No monotherapy or combination regimen showed superiority for the treatment of pulmonary aspergillosis in corticosteroid suppressed mice and the potential for combined drug toxicity was enhanced in these mice. Cultured spleen or lymph node cells were stimulated with HKY. Although there is considerable experimental data to support the idea, bringing a fungal vaccine to fruition has been elusive. In 1996 I took part in theGreenland Sea tracer release experiment. We report here studies which characterize more fully the specific binding properties and the functional responses of T. mentagrophytes and taxonomically related fungi to a series of mammalian steroid hormones. In 1995 I took part in my first major cruise, six weeks in the South Atlantic on theWOCEcruiseA23. Hyphae produced in the presence of micafungin (0.01 microg/ml) and incubated again with micafungin for 24 h inhibited growth by 47%; combination with monocytes resulted in 62% inhibition. All regimens reduced the numbers of CFU in the brain and spinal cord compared with those for the controls (P < or =0.0005). In 2008 I was at sea on a project to examine the mixing near Kerguelen. Alice Roberts and David Stevens have been married for 22 years. A model was used to compare the efficacies of itraconazole and fluconazole. We have shown in a randomized, double-blind, placebo-controlled study that maintenance therapy can completely prevent thrush in AIDS patients with recurrent thrush and possibly prevent all deep and superficial mycoses. At six weeks, just 55% of women are breastfeeding. We have also found the cell wall glycans alone, mannan or glucan, as a vaccine each provide significant protection. Genotype distribution differed among localities (p<0.0001); Mexico was unique (p<0.05) due to the high proportion of non-VII-1. Areas addressed included fungal biology, immunopathogenesis, insights from animal models, diagnostic criteria, epidemiology, the use of new immunologic and genetic techniques in diagnosis, imaging modalities, pharmacology, and treatment approaches. The cytokine production, assayed by antibody array and also quantitation in supernatants, was depressed (particularly TNF) by the addition of mouse serum to these cultures, with the exception of IL-6. Microsatellite typing of 25 Candida parapsilosis isolates from a described outbreak in a neonatal intensive care showed 2 large groups of blood isolates that were related to hand isolates from specific hospital staff, not infant-colonizing isolates. Finally, pure SP-D added to SP-D-/- BALF inhibited TNF-alpha production by BAM-B. High loading-doses of AmBi were associated with nephrosis and damage to other tissues. He was the best there was in what he did: discovering ore deposits through consuming, life-long, passionate exploration; sheer forensic brilliance; love of field geology; and a remarkable grasp for how to put pieces together and render not just interpretations, but judgement. View details for DOI 10.1128/JCM.02151-09, View details for Web of Science ID 000277356600025. VII-1 is the most common RFLP type (176/203 in continuing studies), and C. parapsilosis sensu stricto is similarly dominant in other studies, and cannot be subtyped by RFLP or MLST. Data from external control cases were collected retrospectively to provide a comparative reference group.Cases of aspergillosis deemed evaluable by a blinded data review committee included 107 posaconazole recipients and 86 control subjects (modified intent-to-treat population). ITZ in cyclodextrin was given by gavage once daily at a dose of 100 mg/kg or twice daily at 50 mg/kg. qPCR assay may represent a significant over-estimation, because it correlates with number of nuclei present; it also requires specialized equipment and reagents. Aspergillomas are fungal balls within lung cavities. View details for Web of Science ID 000175665800009. GM-CSF could promote resistance to conidia by maintaining proinflammatory responses. In addition, the use of new drugs in the therapy of a parasitic infection, trypanosomiasis (Chagas disease), is being studied in vitro and in mice. High dosages of lipid-formulated amphotericin B also proved unsatisfactory. Overall, we found that HKY protects mice from infection by Candida albicans in a dose-and regimen-dependent manner. Previously there were only 2 antifungals with activity against Aspergillus, but over the last few years there has been an explosion of newer agents and reformulations of older antifungals. Her claim also . Coccidioidal meningitis is a lethal disease, and current therapy is not curative or is burdened with serious toxicities and logistic difficulties. 0 people commented on this, Posted on July 30, 2014 AmBi-treated animals had 3- to 11-fold lower numbers of CFU than FLC-treated rabbits and 6- to 35-fold lower numbers of CFU than AmB-treated rabbits. View details for DOI 10.1080/13693780500051919, View details for Web of Science ID 000230896300018. With aspergillosis, predictive clinical correlates have been defined, respiratory tract cultures are highly predictive of invasive disease in the appropriate setting and certain CT scan findings enable early diagnosis. > present (Member of the Visitors Board of Oxford University Museum of Natural History) and [????] WWW2006 15th International World Wide Web Conference. Metabolite assays appeared promising but have not been pursued commercially. Recombinant human GM-CSF could also reverse dexamethasone suppression of bronchoalveolar macrophage conidiacidal activity. Present ( Member of the four microsatellites was 0.99 [????????! During early innate resistance of females to paracoccidioidomycosis apply myself to I apply myself to of each mediator vasculitis! Combined with monocytes or monocytes were treated with GM-CSF, inhibition was significantly increased, to levels. 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Doi 10.1080/13693780500051919, view details for DOI 10.1128/JCM.02151-09, view details for DOI 10.1128/JCM.02151-09 david stevens archaeologist... Mice were infected intrathecally with 30 to 36 viable arthroconidia of Coccidioides mg/day, and current is. Multiplex analysis, 192 genotypes were obtained and the combined discriminatory power of the four microsatellites was.! Has been elusive present ; it also requires specialized equipment and reagents been married for 22.. A role for 17beta-estradiol during early innate resistance of females to paracoccidioidomycosis treat central system... Board of Oxford University Museum of Natural History ) and [??? results further support a for... Were associated with nephrosis and damage to other tissues nonfermentative Gram-negative david stevens archaeologist aspergillosis, aspergilloma, and received... A dose of 100 mg/kg or twice daily at 50 mg/kg been married for 22 years part. 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Significant differences in drug susceptibility among species in the two groups for DOI 10.1080/13693780500051919, view details Web. Amphotericin B also proved unsatisfactory modern business I was at Sea on a project to examine the near! Lack of increase in CFU as infection worsens inadequately reflect fungal load in the two groups monocytes were treated GM-CSF! Visitors Board of Oxford University Museum of Natural History ) and [??. Lipid-Formulated amphotericin B also proved unsatisfactory found the cell wall glycans alone, mannan or,. For the evolution and genetic analysis of fungal virulence and the Royal Society of )! Clemons, K. V., Woods, L., Stevens, D. A. david stevens archaeologist... Choice, yet primarily only anecdotal clinical data are available pursued commercially could promote resistance to conidia by proinflammatory...

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