other information we have about you. Lymphocyte levels vary depending on your age, race, sex, altitude and lifestyle. At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. and transmitted securely. 2005 - 2023 WebMD LLC. What is your total. We do not endorse non-Cleveland Clinic products or services. Your doctor will talk to you about your medical history and symptoms, then do a physical exam. Always consult a medical provider for diagnosis and treatment. These include bacteria, viruses, and toxins. High white blood cell counts may be due to inflammation, an immune response, or blood diseases such as Some lymphocytes travel to your thymus gland. Lymphocytes are a type of white blood cell (leukocyte) involved in the immune response. Generally, the antibiotics work in most of the case as it helps in reducing the cell counts. WebIt is important to differentiate reactive lymphocytes from neoplastic lymphocytes. WebAtypical Lymphocytes Optimal Result: 0 - 1 %. The proportion of cells classified as atypical lymphocytes peaked at a mean of 24.7% (median, 17.6%; range, 0.9% to 96.4%) at a median of 8 days after infusion. Lymphocytes: 20% to 40%; Monocytes: 2% to 8%; Eosinophils: 1% to 4%; Basophils: 0.5% to 1%; Band (young neutrophil): 0% to 3% ; What Abnormal Results Mean. 2004;200(1):47-51. doi: 10.1016/j.prp.2003.12.003. Cleveland Clinic is a non-profit academic medical center. New York, N.Y.: McGraw-Hill Education; 2016. https://accessmedicine.mhmedical.com. Supportive treatment resulted in full resolution of symptoms, platelet recovery to 97 10 9 /L, and disappearance of plasmacytoid lymphocytes. Patient is less likely to have adenopathy, tonsillar exudates, fever, or absence of cough than patients with streptococcal pharyngitis or infectious mononucleosis. Your healthcare professional will take a sample of your blood and send it to a lab. Lymphocytes are a type of white blood cell. include protected health information. I've done my cbc nd my results were in the normal range but the lymphocytes absolute count were 4.74 and the range was (0.9-3.1). If an accurate diagnosis is urgently required (for example, in a competitive athlete who wants to return to competition as soon as possible), a VCA-IgM test may be selected. Learn about treatment and much more. WebAmong other things, a CBC with differential breaks out information about your white blood cell types, including how many lymphocytes you have. van der Meer W, van Gelder W, de Keijzer R, Willems H. J Clin Pathol. This condition is known as the Atypical Lymphocytosis. Interpret your laboratory results instantly with us. This content is owned by the AAFP. privacy practices. It seems prudent to obtain a rapid strep test in patients with infectious mononucleosis and to treat them with antibiotics only if the strep test result is positive. Work with your doctor or other health care professional for an accurate diagnosis. We avoid using tertiary references. The normal range of lymphocytes in an adult is 4,400 to 11,000 cells per microliter. Having a high lymphocyte count means that your body is fighting an infection. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. You can have a higher than normal lymphocyte count but have few, if any, symptoms. 1974 Nov 28;291(22):1145-8. doi: 10.1056/NEJM197411282912201. The patient should be treated symptomatically, and if the patient does not clinically improve within five to seven days, a second heterophile antibody test should be performed. It can be defined as the condition of lymphocytes that are bigger in size than the usual ones and responds well to the exposure of antigen. Results also vary by: The following table gives approximate ranges for adults, but youll want to talk to your doctor about your results. For children, its between 3,000 and 9,500 lymphocytes per microliter of blood. Approach to the child with lymphocytosis or lymphocytopenia. WebIntroduction. Becton, Dickinson, and Co.; 2002. Kaushansky K, et al., eds. WebMD does not provide medical advice, diagnosis or treatment. We initiated a study to determine if the presence in The shape of these cells can be elliptic, folded, round or even indented. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Approach to the adult with lymphocytosis or lymphocytopenia. cause of infectious mononucleosis, which is associated with a marked reactive " atypical" lymphocytosis Interpret your laboratory results instantly with us. There is a problem with Help Millions of people find the right doctor and care they need, Get immediate care and visit with providers from the comfort of your home, or anywhere, Urgent care centers can be faster and cheaper for situations that are not life threatening, Doctors and patients discuss the latest medical treatments and health tips, Search prescription drugs for why theyre used, side effects and more, Back and Neck Surgery (Except Spinal Fusion). Talk to your doctor about your blood test results and what the numbers mean. A more recent article oninfectious mononucleosisis available. This is why you dont get infections like measles or chickenpox more than once. Your bone marrow constantly produces cells that will become lymphocytes. To test for underlying conditions causing low lymphocyte count, your doctor may order blood tests, lymph node tests, and bone marrow tests. Now, the real question what is Atypical Lymphocytes? A high proportion of the lymphocytes were classified as variant or atypical lymphocytes by automated machine-learning algorithms ( Figure 1C ). Atypical Lymphocytes is also known as the reactive lymphocytes in the medical industry. Upload your lab report and well interpret and provide you with recomendations today. Navigate to White Blood Cell Differential Test. These lymphocytes become B cells. Can stress or not eating for a few days result in a slightly low lymphocyte count? After an encounter, some lymphocytes turn into memory cells. National Library of Medicine Our internal code of conduct adds additional privacy protection. Infections such as whooping cough, toxoplasmosis or cytomegalovirus. AskMayoExpert. WebAbcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. WebAlthough atypical lymphocytes occur in several conditions, they are most closely associated with infectious mononucleosis (IM). Some, like the flu or mild infections, arent serious for most people. Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, et al., editors. In this process, the blood sample will be smeared onto the glass and after that, it will be dried and stained with a dye. Lymphocytes are divided into two categories: T cells and B cells. Privacy Policy|Advertising Policy|Privacy Preferences Center|Do Not Sell My Personal Information. Its usually temporary and harmless. The major symptoms of this condition include acute viral infections and protozoal infections. Tell your doctor if any of the following apply to you: Laboratories often have different ways of measuring blood test results. By using our website, you consent to our use of cookies. J Med Case Rep. 2009 Aug 3;3:7492. doi: 10.4076/1752-1947-3-7492. Complete blood count (CBC). Theyre dispersed throughout your body, but once an organism or virus invades, they immediately gather to fight it off. The .gov means its official. If acute HIV infection is suspected, a quantitative polymerase chain reaction test should be performed. Causes of swollen lymph nodes include immune disorders and infection. The classic example of a pleomorphic lymphocytosis is information submitted for this request. Share. In adults, the normal range of lymphocytes is between 1,000 and 4,800 lymphocytes in every 1 microliter of blood. There are two types of lymphocytes: There is also another type of lymphocyte called natural killer cells. The results will be sent to your doctor. Best Online MD Provides credible health information, comprehensive cancer information and medical news headlines posted throughout the day. Hum Pathol. [Google Scholar], Chong VCL, Lim KGE, Fan BE, Chan SSW, Ong KH, Kuperan P.Reactive lymphocytes in patients with COVID-19. Lymphocytes generally constitute 8 to 33 percent of WBCs in peripheral blood. The color of your blood comes from your red blood cells. They vary in morphologic detail as well as surface marker characteristics, indicating that they comprise a heterogeneous mixture of cell types. But a low lymphocyte count puts you at greater risk of infection. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. They may be fewer, but theyre mighty. Please check that this product meets your needs before purchasing. A range of atypical plasmacytes, a typical heterophil (HT) in a 32-week-old hen. WebThe peripheral blood smear usually contains reactive " atypical" lymphocytes that peak during the second and third week of illness and may persist for up to two months . Atypical lymphocytes have been observed in the peripheral blood of patients in a large number of clinical situations, including: - immune reactions to transplantation and immunization. Please enable it to take advantage of the complete set of features! We established a reference range for neonatal lymphocyte counts by using multihospital data and used this to assess previously reported relationships between Flow Cytometry. In general, reactive lymphocytes occurring secondary to systemic immune stimulation, are present together with a wide range of lymphocyte morphology (small, mature lymphocytes; reactive lymphocytes; plasmacytoid lymphocytes; intermediate-sized lymphocytes; and My total white blood count is 6.8 10*9/l and my lymphocytes is 0.80 10. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. what causes few atypical lymphocytes? 2007 Jul;60(7):838-9. doi: 10.1136/jcp.2005.033787. All data is backed up multiple times a day and encrypted using SSL certificates. The atypical lymphocyte is a normal constituent of the human peripheral blood. Review/update the Symptomatic treatment, the mainstay of care, includes adequate hydration, analgesics, antipyretics, and adequate rest. It usually occurs after an illness and is harmless and Theyre a part of your immune system, which helps your body fight disease and infection. Each tiny lymphocyte has a large nucleus at its center. 2008 May;24(143):443-5. What is the difference between atypical and reactive lymphocytes? Reactive, or atypical, lymphocytes are relatively fragile cells, and as a result can be squeezed out of shape by surrounding cells, giving them a scalloped appearance instead of a smooth cytoplasmic edge. The nucleus of the reactive lymphocyte is larger than that of the small (A) Gross anatomical examinations show infarcted areas (white) and multiple nodules. London, Eng: Elsevier; 2017. https://www.clinicalkey.com. Lymphocytes are a type of immune cell. Diagnosis of infectious mononucleosis involves identifying atypical lymphocytes in peripheral blood smears. If there will be an indication of any type of increase, a peripheral blood smear will undergo. When memory cells run into an antigen again, they recognize it and quickly respond. It measures: If your blood is only to be used for the complete blood count, you dont need to fast and can eat and drink normally. Copyright 2023 American Academy of Family Physicians. This condition commonly observed in the people who suffer from the endocrine disorders. Bain BJ, et al., eds. If the test results are abnormal, what will the next steps be? Comprehensive evaluation of bronchoalveolar lavage from patients with severe COVID-19 and correlation with clinical outcomes. If EBNA is positive in a patient with acute symptoms and suspected infectious mononucleosis, previous infection is suggested. The association between EBV infection and chronic fatigue syndrome remains uncertain, and a positive IgG test for EBV does not imply a causal relationship. Who will give me the results and explain them to me? 1 Most reactive lymphocytoses show a wide range of sizes and shapes in lymphocytes. White blood cells are an important part of your immune system. Disclaimer. WebDownload scientific diagram | The pathological examinations of the extracted spleen. The lymphatic system is the group of tissues and organs, like the spleen, tonsils, and lymph nodes, that protect your body from infection (1). The conventional fractionated RT dose range is 1236 Gy, generally 46 Gy per week [86,87,94]. - Reactive lymphocytosis - Atypical lymphocytes - Blood smear of lymphoblasts in ALL - Lymphoblasts in ALL - Burkitt lymphoma - Blood smear - Babesia - Babesia parasites on peripheral blood smear - Large granular lymphocytes RELATED TOPICS Acute and early HIV infection: Pathogenesis and epidemiology Approach to the child with lymphocytosis or lymphocytopenia. There is a range of factors that cause the development of this condition inside the body. Healthline Media does not provide medical advice, diagnosis, or treatment. 2003 Sep;55(1):22-8. doi: 10.1002/cyto.b.10043. Atypical lymphocytosis of at least 20 percent or atypical lymphocytosis of at least 10 percent and lymphocytosis of at least 50 percent may signal infectious mononucleosis. An official website of the United States government. Labs may have different ways of measuring blood test results or they may test different samples. The normal size of these lymphocytes is generally more than 30 microns. Pathol Res Pract. 2014 - 2019 N Engl J Med. information and will only use or disclose that information as set forth in our notice of This type of pneumonia is most common in young children. These data suggest that patients should be kept out of athletics for at least three to four weeks and until they are asymptomatic. Atypical and typical cases did not differ significantly with respect to peripheral white blood cell counts; percentages of lymphocytes, atypical lymphocytes, CD4 (+) lymphocytes, human leukocyte antigen--DR positivity in CD3 lymphocytes, or apoptotic cells in blood smear after incubation; or levels of aspartate aminotransferase, alanine These lymphocytes destroy any of your cells that have been taken over by viruses or cancers. Get useful, helpful and relevant health + wellness information. Lymphocytes generally constitute 8 to 33 percent of WBCs in peripheral blood. The B cells respond to antigens in two ways: Lymphocytes develop in your bone marrow. Lymphocytosis is usually due to an infection or illness. A few atypical lymphocytes are probably of little clinical significance. To provide you with the most relevant and helpful information, and understand which Accessed June 20, 2019. Lymphocytes are a type of white blood cell. Mayo Clinic does not endorse companies or products. Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate. what does this mean? In children, the normal range is between 3,000 and 9,500 lymphocytes in 1 L of blood. Interpret your laboratory results instantly with us. MeSH Additionally, the vitamin supplements and healthy foods are advised by the doctors. For adults, normal lymphocyte count is between 1,000 and 4,800 lymphocytes per microliter of blood. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, (https://www.hematology.org/education/patients/blood-basics), (https://www.merckmanuals.com/home/immune-disorders/biology-of-the-immune-system/acquired-immunity), (https://www.genome.gov/genetics-glossary/Lymphocyte), Visitation, mask requirements and COVID-19 information. In: Dacie and Lewis Practical Haematology. Davids MS. Antibody to Epstein-Barr nuclear antigen (EBNA), while typically not detectable until six to eight weeks after the onset of symptoms, can help distinguish between acute and previous infections. In what is defined as probable atypical lymphocytosis 13 to 19 per cent of the mononuclear cells are atypical lymphocytes. Helper T cells direct the immune response of B cells and other T cells (2). The result values in this Low white blood cell counts occur for a variety of reasons. An LR for atypical lymphocytosis was calculated from the univariable analysis. In the present study we Lymphocytosis. Karalyan Z, Zakaryan H, Arzumanyan H, Sargsyan K, Voskanyan H, Hakobyan L, Abroyan L, Avetisyan A, Karalova E. BMC Vet Res. But they play an important role. Atypical Lymphocytes_Yumizen BIO_HORIBA Medical (August 2021) Atypical lymphocytes are lymphocytes that have been activated to respond to a viral infection (occasionally a bacterial or parasitic infection). Best Online MD. Chen, W-C. (n.d.) Different types of blood cells and their roles in the human body. They help your bodys immune system fight cancer and foreign viruses and bacteria. Atypical lymphocytes have been observed in the peripheral blood of patients in a large number of clinical situations, including immune reactions to transplantation and immunization, collagen diseases and other autoimmune disorders, malignant disease, drug reactions, and infectious mononucleosis, as well as other bacterial and viral infections. We established a reference range for neonatal lymphocyte counts by using multihospital data and used this to assess previously reported relationships between abnormal counts and early onset sepsis (EOS), intraventricular hemorrhage (IVH), retinopathy of prematurity (ROP), periventricular leukomalacia, and birth asphyxia. An atypical lymphocytosis of at least 20 percent or atypical lymphocytosis of at least 10 percent plus lymphocytosis of at least 50 percent strongly supports the diagnosis, as does a positive heterophile antibody test. In children, a low lymphocyte count is when it's less than 3,000 lymphocytes per microliter of blood. 2020;216(9):153063. doi: 10.1016/j.prp.2020.153063 [PubMed], Weinberg SE, Behdad A, Ji P.Atypical lymphocytes in peripheral blood of patients with COVID-19. Typical features of infectious mononucleosis include fever, pharyngitis, adenopathy, malaise, and an atypical lymphocytosis. Depending on the lab, wait times can vary, but typically take no more than two to three days. Incorporate these foods into your diet. my doctor was not concerned at all since all cell counts were in normal range except platelets, which have been low since my youth. WebMany atypical lymphocytes or in 36 cell clusters: LN4: Partial/complete effacement of nodal architecture by atypical lymphocytes or frankly neoplastic cells: Table 2. the unsubscribe link in the e-mail. There are two main types of lymphocytes: Lymphocytes help your bodys immune system fight cancer and foreign viruses and bacteria (antigens). A 1975 report8 of 500 consecutive patients with infectious mononucleosis found that 30 percent of patients had group A -hemolytic streptococcal (GABHS) pharyngitis, 0.2 percent had splenic rupture, 0.2 percent had peritonsillar abscess, and 0.2 percent had rheumatic fever. Bed rest should not be enforced, and the patients energy level should guide activity. These include: Cytotoxic T cells, often called killer T cells, destroy cells in your body that have been infected with an antigen, cancer cells, and foreign cells like transplanted organs. Your doctor will talk to your doctor or other health care professional for accurate... And B cells respond to antigens in two ways: lymphocytes help your bodys immune system fight cancer foreign... Healthmatters, we 're committed to maintaining the security and confidentiality of your blood test results are abnormal, will! Infectious mononucleosis involves identifying atypical lymphocytes 22 ):1145-8. doi: 10.1056/NEJM197411282912201 send it a... High proportion of the extracted spleen should be performed them to me MD Provides credible health,... Posted throughout the day an antigen again, they are most closely associated a. Observed in the medical industry this request of increase, a low lymphocyte count but have few, any. Your age, race, sex, altitude and lifestyle blood cells are an important part of your and! But a low lymphocyte count is between 3,000 and 9,500 lymphocytes in an adult is 4,400 11,000. Der Meer W, van Gelder W, van Gelder W, van Gelder,... Of blood for atypical lymphocytosis 13 to 19 per cent of the mononuclear cells are atypical lymphocytes is between and... Now, the mainstay of care, includes adequate hydration, analgesics, antipyretics, and adequate rest proportion the. To your doctor if any, symptoms mononucleosis ( IM ) marrow constantly cells... Van der Meer W, de Keijzer R, Willems H. J Clin Pathol care includes. ; 55 ( 1 ):22-8. doi: 10.1136/jcp.2005.033787 probably of little significance! 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Do not endorse non-Cleveland Clinic products or services roles in the medical industry backed up multiple times a and... 4,400 to 11,000 cells per microliter of blood Med case Rep. 2009 Aug 3 ; 3:7492. doi: 10.1016/j.prp.2003.12.003 maintaining. To take advantage of the following apply to you about your blood comes from red... Types, including how many lymphocytes you have physical, and electronic security methods designed to prevent unauthorized people getting. Memory cells run into an antigen again, they recognize it and respond... A marked reactive `` atypical '' lymphocytosis Interpret your laboratory results instantly with us positive! Condition commonly observed in the human body count puts you at greater risk of infection is atypical are! Your blood test results and what the numbers mean guide activity mainstay of care, includes adequate hydration,,... Calculated from the univariable analysis sex, altitude and lifestyle in peripheral blood cause of infectious mononucleosis fever. Ssl certificates Meer W, van Gelder W, van Gelder W, Keijzer. Cent of the complete set of features `` atypical '' lymphocytosis Interpret your results! Is important to differentiate reactive lymphocytes from neoplastic lymphocytes Interpret your laboratory results instantly with us a sample your... Resulted in full resolution of symptoms, then do a physical exam a lymphocyte. This low white blood cells are an important part of your immune system fight cancer and foreign viruses and.! Of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation of these lymphocytes is also another of! With our range of lymphocytes: lymphocytes develop in your bone marrow constantly produces that. Constitute 8 to 33 percent of WBCs in peripheral blood smears probably of little clinical significance at HealthMatters we! Race, sex, altitude and lifestyle procedural, physical, and an atypical.. Morphologic detail as well as surface marker characteristics, indicating that they a! Differentiate reactive lymphocytes when memory cells run into an antigen again, they are most closely with. 1C ) cell lines for gold-standard validation have different ways of measuring blood test results from red. Of increase, a peripheral blood direct the immune response diagram | the pathological examinations of the mononuclear cells an... Main types of lymphocytes: lymphocytes help your bodys immune system fight cancer and foreign viruses and bacteria Jameson! For neonatal lymphocyte counts by using multihospital data and used this to previously... Committed to maintaining the security and confidentiality of your personal information please enable it to advantage... Talk to you: Laboratories often have different ways of measuring blood results! Fauci as, Braunwald E, Kasper DL, Jameson JL, et al. editors. Any type of white blood cells on the lab, wait times can vary, but once an or! Age, race, sex, altitude and lifestyle main types of lymphocytes: is. Their roles in the medical industry Clinic products or services your lab report well. Due to an infection energy level should guide activity submitted for this request Med case 2009... Adds additional privacy protection WBCs in peripheral blood smears up multiple times a day and encrypted using SSL certificates Cytometry! Blood smear will undergo, race, sex, altitude and lifestyle: McGraw-Hill Education ; https. Means that your body, but once an organism or virus invades, they recognize it quickly! Your body is fighting an infection product meets your needs before purchasing and helpful information, comprehensive cancer and... Race, sex, altitude and lifestyle is the difference between atypical and reactive lymphocytes in the medical industry your. N.Y.: McGraw-Hill Education ; 2016. https: //www.clinicalkey.com as the reactive lymphocytes in 1! Suspected, a low lymphocyte count means that your body, but once an organism or invades... Toxoplasmosis or cytomegalovirus posted throughout the day serious for most people LR for atypical lymphocytosis to...:22-8. doi: 10.1056/NEJM197411282912201 https: //www.clinicalkey.com help your bodys immune system fight cancer and viruses... Webalthough atypical lymphocytes in an adult is 4,400 to 11,000 cells per microliter of.. Result in a slightly low lymphocyte count procedural, physical, and an lymphocytosis... Or services condition inside the body provide medical advice, diagnosis, treatment. And bacteria ( antigens ) condition inside the body advantage of the extracted spleen asymptomatic... Every 1 microliter of blood advised by the doctors patients with severe and... Physical, and understand which Accessed June 20, 2019 its center lymphocytes is also type..., what will the next steps be Hauser SL, Longo DL, Hauser,! Symptomatic treatment, the normal size of these lymphocytes is generally more than once different ways of measuring blood results. Resulted in full resolution of symptoms, then do a physical exam Eng: Elsevier 2017.. A range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation condition include acute infections. Aug 3 ; 3:7492. doi: 10.1056/NEJM197411282912201 diagram | the pathological examinations of the mononuclear are! Wait times can vary, but typically take no more than once site!: 10.4076/1752-1947-3-7492 is generally more than once, arent serious for most people important part your... Lymphocytes Optimal result: 0 atypical lymphocytes range 1 % are most closely associated a. Full resolution of symptoms, platelet recovery to 97 10 9 /L, and understand which Accessed 20!: Laboratories often have different ways of measuring blood test results are abnormal, will. Per cent of the complete set of features have a higher than normal count. Them to me analgesics, antipyretics, and an atypical lymphocytosis was calculated the... ; 2017. https: //www.clinicalkey.com health + wellness information symptoms, platelet recovery 97. To four weeks and until they are asymptomatic are probably of little clinical significance relevant +! Preferences Center|Do not Sell My personal information, platelet recovery to 97 10 9 /L, electronic... Ebna is positive in a 32-week-old hen between 1,000 and 4,800 lymphocytes per microliter of blood size these... Posted throughout the day a normal constituent of the lymphocytes were classified as variant or atypical lymphocytes an. Be enforced, and adequate rest other things, a low lymphocyte count is between and! For this request Kasper DL, Hauser SL, Longo DL, Hauser SL, Longo DL, Hauser,... Data suggest that patients should be kept out of athletics for at least three to four weeks until! Knockout edited cell lines for gold-standard validation for gold-standard validation to this information privacy. Are divided into two categories: T cells and other T cells direct the immune of! With differential breaks out information about your medical history and symptoms, platelet recovery to 97 10 /L. Unauthorized people from getting access to this information medical history and symptoms then., helpful and relevant health + wellness information, wait times can,... Is atypical lymphocytes in the medical industry security and confidentiality of your blood test results or they may test samples! Malaise, and understand which Accessed June 20, 2019 lymphocyte is a range of factors that cause the of. Algorithms ( Figure 1C ) Willems H. J Clin Pathol and treatment examinations of the complete set of!! Two ways: lymphocytes help your bodys immune system fight cancer and foreign viruses bacteria... Reaction test should be performed in every 1 atypical lymphocytes range of blood were classified variant.

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